Mean Kinetic Temperature (MKT) Calculation
MKT is defined by the United States Pharmacopeia as the "single calculated temperature at which the total amount of degradation over a particular period is equal to the sum of the individual degradations thhat would occur at various temperatures".

Scientek Software provides a wealth of background information on MKT, as well as a free software tool to calculate MKT.

LINK:  www.stabilitysystem.com/II/
 "Taking a cost-effective approach to drug and biologic shipments"
This article from Healthcare Packaging discusses the importance of understanding a product stability profile, the distribution environment (temperature & humidity), and a company's risk tolerance, for a successful cold chain program.  The role of operational qualification (worst case laboratory testing) and performance qualification (field testing) are also covered.  Click here for the full article.
 "10 essential considerations for a validated, temperature-controlled package"
This article from Kevin O'Donnell in the Advanced Degrees column of Contract Pharma discusses 10 key areas to consider when designing, evaluating and implementing active or passive cold chain packaging.  Click here for full article.
"Shipping temperature-sensitive goods with phase-change materials: A primer"
This article from Healthcare Packaging discusses how phase change materials (PCM) work to maintain temperatures in thermal packaging, how to evaluate these materials, and the type of PCM's currently available in the market.  Click here for full article.
"Cold-chain delivery upsets are being noticed by physicians, says Temptime survey"
08-27-2010 , News
This news report discusses the result of a Harris Interactive survey sponsored by TempTime Corp., which evaluates physician's experiences with temperature issues and their confidence in the management of the cold chain.  The survey indicates that "almost three-quarters of physicians have experienced a “cold chain break” in drugs they’ve prescribed; less than a third are “very confident” that the cold chain is being properly managed".  Click here for the news article.
 
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